| 3. Jornada | 20.02.2022 | Atlético Chiriquí | - | San Francisco FC | 2:1 |  |
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| 4. Jornada | 26.02.2022 | San Francisco FC | - | UD Universitario | 0:1 | ||||
| 5. Jornada | 05.03.2022 | Herrera FC | - | San Francisco FC | 0:0 | ||||
| 6. Jornada | 09.03.2022 | San Francisco FC | - | Árabe Unido | 0:0 | ||||
| 7. Jornada | 14.03.2022 | Alianza | - | San Francisco FC | 2:1 |
Panamá