| 1. Jornada | 28.08.2021 | Real Unión | - | Inter de Madrid | 2:1 |  |
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| 2. Jornada | 05.09.2021 | Valladolid B | - | Real Unión | 0:2 | |
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| 3. Jornada | 10.09.2021 | Real Unión | - | Celta B | 1:4 | ||||
| 4. Jornada | 19.09.2021 | UD Logroñés | - | Real Unión | 1:0 | ||||
| 5. Jornada | 25.09.2021 | Real Unión | - | CD Badajoz | 1:2 | ||||
| 6. Jornada | 03.10.2021 | Rayo Majadahonda | - | Real Unión | 1:0 | ||||
| 7. Jornada | 09.10.2021 | Real Unión | - | Deportivo | 2:1 | ||||
| 8. Jornada | 15.10.2021 | CD Calahorra | - | Real Unión | 2:4 | ||||
| 10. Jornada | 31.10.2021 | Real Unión | - | Real Racing | 1:2 | |
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| 13. Jornada | 21.11.2021 | SD Logroñés | - | Real Unión | 0:2 | ||||
| 17. Jornada | 19.12.2021 | CF Talavera | - | Real Unión | 1:3 | ||||
| 24. Jornada | 19.02.2022 | Real Unión | - | SD Logroñés | 2:1 | ||||
| 25. Jornada | 27.02.2022 | Real Racing | - | Real Unión | 4:1 | ||||
| 21. Jornada | 02.03.2022 | Real Unión | - | Valladolid B | 2:1 | |
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| 26. Jornada | 06.03.2022 | Real Unión | - | CD Calahorra | 0:2 | |
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| 31. Jornada | 10.04.2022 | Zamora CF | - | Real Unión | 0:1 | ||||
| 35. Jornada | 08.05.2022 | Inter de Madrid | - | Real Unión | 2:0 | ||||
| 36. Jornada | 14.05.2022 | Real Unión | - | CF Talavera | 3:1 | ||||
| 38. Jornada | 28.05.2022 | Real Unión | - | CD Tudelano | 3:1 |
España