| 16. Jornada | 06.12.2020 | Real Potosí | - | The Strongest | 3:5 |  |
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| 17. Jornada | 09.12.2020 | Real Santa Cruz | - | Real Potosí | 3:1 | |
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| 18. Jornada | 11.12.2020 | Club San José | - | Real Potosí | 1:2 |  |
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| 20. Jornada | 18.12.2020 | Jorge Wilstermann | - | Real Potosí | 3:1 | ||||
| 22. Jornada | 22.12.2020 | Atlético Palmaflor | - | Real Potosí | 0:0 | ||||
| 23. Jornada | 26.12.2020 | Real Potosí | - | Bolívar | 2:3 | ||||
| 24. Jornada | 27.12.2020 | Royal Pari | - | Real Potosí | 1:1 | |
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| 25. Jornada | 29.12.2020 | Real Potosí | - | Nacional Potosí | 2:3 | ||||
| 26. Jornada | 31.12.2020 | CD Guabirá | - | Real Potosí | 4:0 |
Bolivia