| 3. Jornada | 03.04.2022 | Inter Miami CF | - | Houston Dynamo | 1:3 | ||||
| 3. Jornada | 10.04.2022 | Houston Dynamo | - | San Jose Earthquakes | 4:3 |  |
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| 3. Jornada | 17.04.2022 | Houston Dynamo | - | Portland Timbers | 0:0 | ||||
| 3. Jornada | 23.04.2022 | FC Dallas | - | Houston Dynamo | 2:1 | |
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| 4. Jornada | 15.05.2022 | Houston Dynamo | - | Nashville SC | 2:0 | ||||
| 4. Jornada | 19.05.2022 | Houston Dynamo | - | Seattle Sounders | 0:1 | ||||
| 4. Jornada | 23.05.2022 | Los Angeles Galaxy | - | Houston Dynamo | 0:3 | ||||
| 5. Jornada | 19.06.2022 | Orlando City | - | Houston Dynamo | 2:1 | ||||
| 6. Jornada | 18.07.2022 | San Jose Earthquakes | - | Houston Dynamo | 1:2 | ||||
| 7. Jornada | 06.08.2022 | Vancouver Whitecaps | - | Houston Dynamo | 2:1 | ||||
| 7. Jornada | 14.08.2022 | Houston Dynamo | - | CF Montréal | 2:3 | ||||
| 7. Jornada | 01.09.2022 | Houston Dynamo | - | Los Angeles FC | 2:1 | ||||
| 8. Jornada | 05.09.2022 | Seattle Sounders | - | Houston Dynamo | 2:1 | ||||
| 8. Jornada | 11.09.2022 | Houston Dynamo | - | Sporting Kansas City | 0:0 | ||||
| 9. Jornada | 09.10.2022 | Houston Dynamo | - | Los Angeles Galaxy | 1:3 |
Estados Unidos