| 1. Jornada | 11.03.2012 | Colorado Rapids | - | Columbus Crew | 2:0 | ||||
| 1. Jornada | 24.03.2012 | Columbus Crew | - | Impact de Montréal | 2:0 | ||||
| 1. Jornada | 31.03.2012 | Toronto FC | - | Columbus Crew | 0:1 | ||||
| 2. Jornada | 07.04.2012 | Columbus Crew | - | New York RB | 1:4 | ||||
| 2. Jornada | 14.04.2012 | Philadelphia Union | - | Columbus Crew | 1:0 | ||||
| 2. Jornada | 22.04.2012 | Columbus Crew | - | Houston Dynamo | 2:2 | ||||
| 2. Jornada | 29.04.2012 | Columbus Crew | - | Vancouver Whitecaps | 0:1 | ||||
| 3. Jornada | 06.05.2012 | Portland Timbers | - | Columbus Crew | 0:0 | ||||
| 3. Jornada | 13.05.2012 | Columbus Crew | - | FC Dallas | 2:1 | ||||
| 4. Jornada | 17.06.2012 | New England Revolution | - | Columbus Crew | 0:0 | ||||
| 4. Jornada | 24.06.2012 | Chicago Fire | - | Columbus Crew | 2:1 | ||||
| 5. Jornada | 22.07.2012 | Columbus Crew | - | D.C. United | 1:0 | ||||
| 5. Jornada | 29.07.2012 | Sporting Kansas City | - | Columbus Crew | 1:2 | ||||
| 6. Jornada | 05.08.2012 | D.C. United | - | Columbus Crew | 1:0 | ||||
| 6. Jornada | 20.08.2012 | Houston Dynamo | - | Columbus Crew | 2:2 |
Estados Unidos
Canadá 
