| 1. Jornada | 25.02.2022 | Academia Puerto Cabello | - | Portuguesa FC | 1:1 | ||||
| 2. Jornada | 06.03.2022 | Deportivo La Guaira | - | Academia Puerto Cabello | 2:1 |  |
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| 3. Jornada | 11.03.2022 | Academia Puerto Cabello | - | Aragua FC | 2:1 | ||||
| 4. Jornada | 18.03.2022 | Deportivo Táchira | - | Academia Puerto Cabello | 1:1 | ||||
| 5. Jornada | 25.03.2022 | Hermanos Colmenarez | - | Academia Puerto Cabello | 4:1 | ||||
| 6. Jornada | 01.04.2022 | Academia Puerto Cabello | - | Caracas FC | 0:0 | |
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| 7. Jornada | 10.04.2022 | Mineros de Guayana | - | Academia Puerto Cabello | 2:0 | |
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| 8. Jornada | 15.04.2022 | Academia Puerto Cabello | - | Monagas | 0:2 | ||||
| 10. Jornada | 30.04.2022 | Academia Puerto Cabello | - | Estudiantes de Mérida | 1:0 | ||||
| 11. Jornada | 08.05.2022 | Universidad Central | - | Academia Puerto Cabello | 2:2 | ||||
| 12. Jornada | 15.05.2022 | Academia Puerto Cabello | - | Carabobo FC | 1:1 | ||||
| 13. Jornada | 20.05.2022 | Zamora FC | - | Academia Puerto Cabello | 1:0 | ||||
| 14. Jornada | 30.05.2022 | Academia Puerto Cabello | - | Metropolitanos FC | 0:2 | ||||
| 15. Jornada | 04.06.2022 | Zulia FC | - | Academia Puerto Cabello | 4:1 |
Panamá