| 2. Jornada | 22.02.2022 | Deportes Temuco | - | Santiago Wanderers | 1:0 | ||||
| 3. Jornada | 02.03.2022 | Santiago Wanderers | - | Santiago Morning | 2:2 |  |
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| 4. Jornada | 10.03.2022 | San Luis | - | Santiago Wanderers | 1:1 |  |
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| 5. Jornada | 17.03.2022 | Santiago Wanderers | - | Rangers | 1:3 | |
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| 6. Jornada | 22.03.2022 | Fernández Vial | - | Santiago Wanderers | 0:0 | ||||
| 7. Jornada | 03.04.2022 | Santiago Wanderers | - | CD Magallanes | 0:2 | ||||
| 8. Jornada | 09.04.2022 | Deportes Copiapó | - | Santiago Wanderers | 1:1 | ||||
| 9. Jornada | 16.04.2022 | Santiago Wanderers | - | Puerto Montt | 2:0 | |
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| 13. Jornada | 07.05.2022 | Santiago Wanderers | - | Barnechea | 1:3 | ||||
| 14. Jornada | 13.05.2022 | Cobreloa | - | Santiago Wanderers | 1:1 | |
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| 17. Jornada | 28.05.2022 | Santa Cruz | - | Santiago Wanderers | 2:0 | ||||
| 1. Jornada | 05.06.2022 | Santiago Wanderers | - | Deportes Iquique | 2:0 | ||||
| 11. Jornada | 10.06.2022 | Santiago Wanderers | - | Unión San Felipe | 0:1 |
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