| 6. Jornada | 10.09.2021 | Stade Lausanne-Ouchy | - | FC Schaffhausen | 2:1 | ||||
| 7. Jornada | 21.09.2021 | FC Schaffhausen | - | FC Thun | 2:1 | ||||
| 8. Jornada | 24.09.2021 | FC Wil 1900 | - | FC Schaffhausen | 2:0 | ||||
| 9. Jornada | 01.10.2021 | FC Schaffhausen | - | Neuchâtel Xamax FCS | 4:0 | ||||
| 10. Jornada | 16.10.2021 | SC Kriens | - | FC Schaffhausen | 0:0 | ||||
| 11. Jornada | 23.10.2021 | FC Vaduz | - | FC Schaffhausen | 2:1 |  |
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| 12. Jornada | 30.10.2021 | FC Schaffhausen | - | FC Wil 1900 | 3:3 |  |
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| 13. Jornada | 05.11.2021 | Neuchâtel Xamax FCS | - | FC Schaffhausen | 0:3 | ||||
| 14. Jornada | 19.11.2021 | FC Schaffhausen | - | FC Aarau | 2:0 | ||||
| 15. Jornada | 26.11.2021 | FC Winterthur | - | FC Schaffhausen | 2:5 | ||||
| 16. Jornada | 03.12.2021 | Yverdon Sport FC | - | FC Schaffhausen | 2:1 | ||||
| 17. Jornada | 11.12.2021 | FC Schaffhausen | - | Stade Lausanne-Ouchy | 1:0 |
Suiza