| 1. Jornada | 18.07.2021 | River Plate | - | Colón de Santa Fe | 1:2 | ||||
| 2. Jornada | 25.07.2021 | River Plate | - | Unión de Santa Fe | 4:0 | ||||
| 3. Jornada | 29.07.2021 | CA Lanús | - | River Plate | 0:3 | ||||
| 4. Jornada | 01.08.2021 | River Plate | - | Huracán | 1:1 | ||||
| 5. Jornada | 08.08.2021 | Godoy Cruz | - | River Plate | 2:1 | ||||
| 6. Jornada | 14.08.2021 | River Plate | - | Vélez Sarsfield | 2:0 | ||||
| 11. Jornada | 16.09.2021 | Newell's Old Boys | - | River Plate | 1:4 |  |
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| 12. Jornada | 20.09.2021 | River Plate | - | Arsenal de Sarandí | 1:0 | ||||
| 13. Jornada | 26.09.2021 | Central Córdoba SdE | - | River Plate | 1:3 | ||||
| 14. Jornada | 03.10.2021 | River Plate | - | Boca Juniors | 2:1 | ||||
| 15. Jornada | 09.10.2021 | Banfield | - | River Plate | 0:1 | |
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| 19. Jornada | 01.11.2021 | Estudiantes | - | River Plate | 1:1 |
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