| Grupo 4 | 23.04.2021 | Fluminense RJ | - | River Plate | 1:1 | ||||
| Grupo 4 | 29.04.2021 | River Plate | - | Atlético Junior | 2:1 | ||||
| Grupo 4 | 13.05.2021 | Atlético Junior | - | River Plate | 1:1 | ||||
| Grupo 4 | 20.05.2021 | River Plate | - | Santa Fe | 2:1 |  |
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| Octavos de final | 15.07.2021 | River Plate | - | Argentinos Juniors | 1:1 | ||||
| Octavos de final | 22.07.2021 | Argentinos Juniors | - | River Plate | 0:2 | ||||
| Cuartos de final | 12.08.2021 | River Plate | - | Atlético Mineiro | 0:1 | ||||
| Cuartos de final | 19.08.2021 | Atlético Mineiro | - | River Plate | 3:0 |
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