| 7. Jornada | 25.08.2021 | Sporting FC | - | AD San Carlos | 0:0 | ||||
| 8. Jornada | 30.08.2021 | AD San Carlos | - | AD Guanacasteca | 0:1 | ||||
| 9. Jornada | 08.09.2021 | Santos de Guápiles | - | AD San Carlos | 2:2 |  |
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| 10. Jornada | 13.09.2021 | AD San Carlos | - | Deportivo Saprissa | 1:0 | ||||
| 12. Jornada | 18.09.2021 | LD Alajuelense | - | AD San Carlos | 2:2 | ||||
| 13. Jornada | 26.09.2021 | AD San Carlos | - | Guadalupe | 4:2 | ||||
| 14. Jornada | 03.10.2021 | Municipal Pérez Zeledón | - | AD San Carlos | 1:1 | ||||
| 15. Jornada | 13.10.2021 | AD San Carlos | - | CS Cartaginés | 0:1 | |
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| 16. Jornada | 17.10.2021 | Jicaral | - | AD San Carlos | 0:4 | ||||
| 17. Jornada | 23.10.2021 | AD San Carlos | - | CS Herediano | 0:0 | ||||
| 18. Jornada | 28.10.2021 | AD San Carlos | - | Sporting FC | 3:1 |  |
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| 19. Jornada | 01.11.2021 | AD Guanacasteca | - | AD San Carlos | 0:1 | ||||
| 20. Jornada | 21.11.2021 | AD San Carlos | - | Santos de Guápiles | 2:4 | ||||
| 21. Jornada | 24.11.2021 | Deportivo Saprissa | - | AD San Carlos | 3:0 |
Costa Rica