| 1. Jornada | 03.06.2021 | Defensor Sporting | - | Rocha | 2:1 | ||||
| 6. Jornada | 09.07.2021 | Defensor Sporting | - | Racing | 1:4 | ||||
| 7. Jornada | 15.07.2021 | Villa Teresa | - | Defensor Sporting | 0:2 |  |
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| 8. Jornada | 22.07.2021 | Defensor Sporting | - | Juventud de Las Piedras | 1:2 | ||||
| 9. Jornada | 28.07.2021 | Uruguay Montevideo | - | Defensor Sporting | 0:2 | |
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| 12. Jornada | 16.09.2021 | Rocha | - | Defensor Sporting | 1:2 | ||||
| 15. Jornada | 05.10.2021 | Central Español | - | Defensor Sporting | 1:0 | |
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| 16. Jornada | 12.10.2021 | Defensor Sporting | - | Atenas | 1:1 | ||||
| 20. Jornada | 10.11.2021 | Defensor Sporting | - | Uruguay Montevideo | 2:0 | ||||
| 21. Jornada | 18.11.2021 | Rampla Juniors | - | Defensor Sporting | 0:5 | ||||
| 22. Jornada | 24.11.2021 | Defensor Sporting | - | Danubio | 0:1 |
Uruguay