| 4. Jornada | 29.01.2012 | Club San Luis | - | CF América | 1:3 | ||||
| 5. Jornada | 05.02.2012 | CF Monterrey | - | Club San Luis | 3:0 | ||||
| 6. Jornada | 12.02.2012 | Club San Luis | - | UANL Tigres | 0:2 | ||||
| 7. Jornada | 19.02.2012 | Deportivo Guadalajara | - | Club San Luis | 0:0 | ||||
| 8. Jornada | 26.02.2012 | Club San Luis | - | Atlas Guadalajara | 0:1 | ||||
| 9. Jornada | 04.03.2012 | Santos Laguna | - | Club San Luis | 5:2 |  |
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| 10. Jornada | 11.03.2012 | Club San Luis | - | CF Pachuca | 0:0 |  |
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| 11. Jornada | 18.03.2012 | Puebla FC | - | Club San Luis | 0:1 | ||||
| 12. Jornada | 25.03.2012 | Club San Luis | - | Atlante | 2:3 | ||||
| 13. Jornada | 01.04.2012 | Cruz Azul | - | Club San Luis | 3:1 | ||||
| 14. Jornada | 08.04.2012 | Club San Luis | - | Jaguares Chiapas | 2:3 | ||||
| 15. Jornada | 15.04.2012 | Gallos Blancos (old) | - | Club San Luis | 2:2 | |
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| 16. Jornada | 22.04.2012 | Club San Luis | - | Club Tijuana | 0:1 | ||||
| 17. Jornada | 29.04.2012 | Deportivo Toluca | - | Club San Luis | 2:1 | |
Argentina