| 1. Jornada | 21.07.2018 | Boston River | - | River Plate | 2:3 |  |
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| 2. Jornada | 29.07.2018 | River Plate | - | Peñarol | 0:1 | |
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| 3. Jornada | 04.08.2018 | Atenas | - | River Plate | 1:1 | |
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| 4. Jornada | 12.08.2018 | River Plate | - | Danubio | 1:2 | ||||
| 5. Jornada | 19.08.2018 | Torque | - | River Plate | 3:0 | ||||
| 6. Jornada | 26.08.2018 | River Plate | - | Rampla Juniors | 3:4 | ||||
| 7. Jornada | 01.09.2018 | Fénix | - | River Plate | 1:3 | |
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| 12. Jornada | 14.10.2018 | CA Cerro | - | River Plate | 4:2 | ||||
| 14. Jornada | 28.10.2018 | Liverpool | - | River Plate | 4:1 | |
Uruguay