| 1. Jornada | 10.01.2021 | CF América | - | Atlético San Luis | 2:1 |  |
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| 2. Jornada | 16.01.2021 | Club Necaxa | - | Atlético San Luis | 1:0 | ||||
| 9. Jornada | 03.03.2021 | Atlas Guadalajara | - | Atlético San Luis | 3:1 | ||||
| 10. Jornada | 06.03.2021 | Atlético San Luis | - | Deportivo Toluca | 0:0 | ||||
| 11. Jornada | 15.03.2021 | Gallos Blancos | - | Atlético San Luis | 2:1 | ||||
| 12. Jornada | 21.03.2021 | Atlético San Luis | - | Pumas UNAM | 0:1 | ||||
| 13. Jornada | 04.04.2021 | CF Monterrey | - | Atlético San Luis | 2:0 | |
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| 14. Jornada | 10.04.2021 | FC Juárez | - | Atlético San Luis | 2:1 | ||||
| 15. Jornada | 18.04.2021 | Atlético San Luis | - | Puebla FC | 1:4 |
Uruguay
Italia