| 3. Jornada | 18.07.2022 | UANL Tigres | - | Club Tijuana | 1:0 | ||||
| 4. Jornada | 24.07.2022 | Club Tijuana | - | CF América | 2:0 | ||||
| 5. Jornada | 27.07.2022 | Atlas Guadalajara | - | Club Tijuana | 1:2 | ||||
| 6. Jornada | 31.07.2022 | Club Tijuana | - | Mazatlán FC | 2:0 |  |
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| 7. Jornada | 07.08.2022 | Deportivo Toluca | - | Club Tijuana | 3:1 | ||||
| 8. Jornada | 13.08.2022 | Club Tijuana | - | Puebla FC | 3:3 | |
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| 9. Jornada | 18.08.2022 | Cruz Azul | - | Club Tijuana | 1:2 | ||||
| 10. Jornada | 21.08.2022 | Gallos Blancos | - | Club Tijuana | 2:0 | ||||
| 16. Jornada | 26.08.2022 | Club Tijuana | - | Santos Laguna | 0:2 | |
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| 11. Jornada | 29.08.2022 | Club Tijuana | - | CF Monterrey | 0:3 | ||||
| 12. Jornada | 02.09.2022 | Atlético San Luis | - | Club Tijuana | 0:0 | |
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| 13. Jornada | 08.09.2022 | Club Tijuana | - | Deportivo Guadalajara | 1:2 | ||||
| 14. Jornada | 12.09.2022 | CF Pachuca | - | Club Tijuana | 6:1 | ||||
| 15. Jornada | 19.09.2022 | Club Tijuana | - | Club Necaxa | 1:1 |  |
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| 17. Jornada | 03.10.2022 | Club León | - | Club Tijuana | 2:2 |
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