| 1. Jornada | 17.03.2012 | Impact de Montréal | - | Chicago Fire | 1:1 | ||||
| 1. Jornada | 25.03.2012 | Chicago Fire | - | Philadelphia Union | 1:0 | ||||
| 2. Jornada | 02.04.2012 | Colorado Rapids | - | Chicago Fire | 2:0 | ||||
| 2. Jornada | 21.04.2012 | Toronto FC | - | Chicago Fire | 2:3 | ||||
| 2. Jornada | 29.04.2012 | Chicago Fire | - | Seattle Sounders | 1:2 | ||||
| 3. Jornada | 05.05.2012 | CD Chivas | - | Chicago Fire | 1:2 | ||||
| 3. Jornada | 10.05.2012 | Chicago Fire | - | Real Salt Lake | 0:0 | ||||
| 3. Jornada | 13.05.2012 | Chicago Fire | - | Sporting Kansas City | 2:1 |  |
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| 3. Jornada | 21.05.2012 | Portland Timbers | - | Chicago Fire | 2:1 | ||||
| 3. Jornada | 27.05.2012 | Columbus Crew | - | Chicago Fire | 2:1 | ||||
| 4. Jornada | 03.06.2012 | New England Revolution | - | Chicago Fire | 2:0 |
Uruguay