| 1. Jornada | 22.08.2021 | Reggina 1914 | - | AC Monza | 0:0 | ||||
| 2. Jornada | 29.08.2021 | Reggina 1914 | - | Ternana Calcio | 3:2 | ||||
| 3. Jornada | 11.09.2021 | FC Crotone | - | Reggina 1914 | 1:1 | ||||
| 4. Jornada | 18.09.2021 | Reggina 1914 | - | SPAL 2013 Ferrara | 2:1 | ||||
| 5. Jornada | 21.09.2021 | Pordenone Calcio | - | Reggina 1914 | 1:1 | ||||
| 6. Jornada | 25.09.2021 | Reggina 1914 | - | Frosinone | 0:0 | ||||
| 8. Jornada | 16.10.2021 | L.R. Vicenza | - | Reggina 1914 | 0:1 | ||||
| 10. Jornada | 28.10.2021 | AC Perugia Calcio | - | Reggina 1914 | 0:2 |  |
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| 11. Jornada | 01.11.2021 | Reggina 1914 | - | AS Cittadella | 0:1 | |
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| 12. Jornada | 05.11.2021 | Cosenza Calcio | - | Reggina 1914 | 0:1 | ||||
| 14. Jornada | 27.11.2021 | Benevento Calcio | - | Reggina 1914 | 4:0 | ||||
| 16. Jornada | 04.12.2021 | US Lecce | - | Reggina 1914 | 2:0 | ||||
| 17. Jornada | 12.12.2021 | Reggina 1914 | - | US Alessandria 1912 | 0:4 | ||||
| 19. Jornada | 15.01.2022 | Reggina 1914 | - | Brescia Calcio | 0:2 | ||||
| 20. Jornada | 22.01.2022 | AC Monza | - | Reggina 1914 | 1:0 | |
Italia