| 1. Jornada | 06.01.2013 | Club San Luis | - | Santos Laguna | 1:1 |  |
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| 2. Jornada | 12.01.2013 | Santos Laguna | - | Deportivo Guadalajara | 2:0 | ||||
| 3. Jornada | 20.01.2013 | Puebla FC | - | Santos Laguna | 2:1 | |
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| 4. Jornada | 26.01.2013 | Santos Laguna | - | Club León | 2:0 | ||||
| 5. Jornada | 03.02.2013 | Pumas UNAM | - | Santos Laguna | 0:0 | ||||
| 6. Jornada | 10.02.2013 | Santos Laguna | - | CF Pachuca | 0:1 | |
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| 7. Jornada | 17.02.2013 | UANL Tigres | - | Santos Laguna | 1:1 | ||||
| 8. Jornada | 23.02.2013 | Santos Laguna | - | CF América | 1:0 | ||||
| 9. Jornada | 02.03.2013 | Jaguares Chiapas | - | Santos Laguna | 1:3 | |
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| 10. Jornada | 10.03.2013 | Santos Laguna | - | Atlante | 2:1 | ||||
| 11. Jornada | 17.03.2013 | Atlas Guadalajara | - | Santos Laguna | 1:2 | |
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| 12. Jornada | 31.03.2013 | Santos Laguna | - | Gallos Blancos (old) | 1:1 | ||||
| 13. Jornada | 07.04.2013 | Club Tijuana | - | Santos Laguna | 0:0 | ||||
| 14. Jornada | 13.04.2013 | Santos Laguna | - | Deportivo Toluca | 2:1 | ||||
| 15. Jornada | 20.04.2013 | Santos Laguna | - | CF Monterrey | 1:0 |  |
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| 17. Jornada | 05.05.2013 | Santos Laguna | - | Monarcas Morelia | 1:2 | |
Panamá
México 