| 1. Jornada | 25.07.2018 | América de Cali | - | Leones FC | 1:0 |  |
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| 2. Jornada | 31.07.2018 | Leones FC | - | Alianza Petrolera | 0:1 | ||||
| 3. Jornada | 07.08.2018 | Jaguares de Córdoba | - | Leones FC | 2:0 | |
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| 4. Jornada | 11.08.2018 | Leones FC | - | Atlético Bucaramanga | 0:1 | |
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| 5. Jornada | 22.08.2018 | Deportivo Pasto | - | Leones FC | 2:1 | |
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| 6. Jornada | 25.08.2018 | Leones FC | - | Envigado FC | 1:1 | ||||
| 7. Jornada | 01.09.2018 | Atlético Huila | - | Leones FC | 2:3 | ||||
| 8. Jornada | 04.09.2018 | Leones FC | - | Boyacá Chicó | 1:2 | ||||
| 9. Jornada | 09.09.2018 | Independiente Medellín | - | Leones FC | 1:1 | ||||
| 10. Jornada | 15.09.2018 | Leones FC | - | Deportivo Cali | 0:0 | ||||
| 11. Jornada | 23.09.2018 | Águilas Doradas | - | Leones FC | 2:1 | ||||
| 12. Jornada | 29.09.2018 | Leones FC | - | Atlético Junior | 2:2 | |
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| 14. Jornada | 14.10.2018 | Leones FC | - | La Equidad | 0:1 | ||||
| 15. Jornada | 19.10.2018 | Millonarios | - | Leones FC | 1:0 | ||||
| 16. Jornada | 21.10.2018 | Deportes Tolima | - | Leones FC | 3:2 | |
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| 17. Jornada | 27.10.2018 | Leones FC | - | Santa Fe | 0:2 | |
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| 18. Jornada | 04.11.2018 | Patriotas FC | - | Leones FC | 2:1 | |
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| 19. Jornada | 11.11.2018 | Leones FC | - | Atlético Nacional | 2:2 | |
Colombia