| 1. Jornada | 10.02.2022 | Newell's Old Boys II | - | Defensa y Justicia II | 2:0 | ||||
| 2. Jornada | 15.02.2022 | Argentinos Juniors II | - | Newell's Old Boys II | 1:1 | ||||
| 4. Jornada | 24.02.2022 | Talleres de Córdoba II | - | Newell's Old Boys II | 2:2 | ||||
| 6. Jornada | 10.03.2022 | Sarmiento de Junín II | - | Newell's Old Boys II | 1:2 |  |
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| 10. Jornada | 13.04.2022 | Newell's Old Boys II | - | Patronato de Paraná II | 1:0 | ||||
| 11. Jornada | 19.04.2022 | Newell's Old Boys II | - | Banfield II | 1:0 | ||||
| 12. Jornada | 26.04.2022 | Racing Club II | - | Newell's Old Boys II | 1:1 |
Argentina