| 17. Jornada | 28.08.2021 | Rangers | - | San Luis | 0:1 |  |
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| 18. Jornada | 01.09.2021 | San Luis | - | Puerto Montt | 0:1 | ||||
| 19. Jornada | 07.09.2021 | Unión San Felipe | - | San Luis | 1:1 | ||||
| 20. Jornada | 16.09.2021 | San Luis | - | Deportes Iquique | 1:1 |  |
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| 21. Jornada | 22.09.2021 | Fernández Vial | - | San Luis | 2:2 | |
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| 22. Jornada | 26.09.2021 | Deportes Copiapó | - | San Luis | 4:1 | ||||
| 25. Jornada | 12.10.2021 | San Luis | - | Santa Cruz | 0:0 | ||||
| 26. Jornada | 21.10.2021 | San Luis | - | Santiago Morning | 2:2 | ||||
| 27. Jornada | 25.10.2021 | Universidad de Concepción | - | San Luis | 0:2 | ||||
| 28. Jornada | 31.10.2021 | San Luis | - | Coquimbo Unido | 0:0 | ||||
| 29. Jornada | 06.11.2021 | CD Magallanes | - | San Luis | 3:3 | |
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| 30. Jornada | 12.11.2021 | San Luis | - | Barnechea | 2:1 | |
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