| 3. Jornada | 26.04.2021 | Puerto Montt | - | San Luis | 2:1 |  |
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| 4. Jornada | 03.05.2021 | San Luis | - | Unión San Felipe | 1:2 | |
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| 5. Jornada | 09.05.2021 | Deportes Iquique | - | San Luis | 0:0 | ||||
| 7. Jornada | 25.05.2021 | San Luis | - | Deportes Copiapó | 1:2 | ||||
| 8. Jornada | 30.05.2021 | Cobreloa | - | San Luis | 1:0 | ||||
| 9. Jornada | 07.06.2021 | San Luis | - | San Marcos | 0:1 | |
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| 10. Jornada | 11.07.2021 | Santa Cruz | - | San Luis | 2:0 | ||||
| 11. Jornada | 15.07.2021 | Santiago Morning | - | San Luis | 0:0 | |
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| 12. Jornada | 23.07.2021 | San Luis | - | Universidad de Concepción | 1:0 | |
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| 13. Jornada | 01.08.2021 | Coquimbo Unido | - | San Luis | 0:1 | ||||
| 15. Jornada | 17.08.2021 | Barnechea | - | San Luis | 0:0 | ||||
| 16. Jornada | 23.08.2021 | San Luis | - | Deportes Temuco | 1:1 | ||||
| 17. Jornada | 28.08.2021 | Rangers | - | San Luis | 0:1 | ||||
| 18. Jornada | 01.09.2021 | San Luis | - | Puerto Montt | 0:1 |
Chile