| 1. Jornada | 08.01.2022 | FC Juárez | - | Club Necaxa | 2:1 | ||||
| 2. Jornada | 15.01.2022 | Club Necaxa | - | CF Monterrey | 0:4 | ||||
| 3. Jornada | 24.01.2022 | Santos Laguna | - | Club Necaxa | 1:4 | ||||
| 4. Jornada | 06.02.2022 | Club Necaxa | - | CF Pachuca | 1:3 |  |
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| 5. Jornada | 13.02.2022 | Cruz Azul | - | Club Necaxa | 1:2 | ||||
| 6. Jornada | 19.02.2022 | Club Tijuana | - | Club Necaxa | 1:1 | ||||
| 7. Jornada | 26.02.2022 | Club Necaxa | - | Club León | 0:1 | ||||
| 8. Jornada | 02.03.2022 | Mazatlán FC | - | Club Necaxa | 0:0 | ||||
| 9. Jornada | 05.03.2022 | Club Necaxa | - | Deportivo Toluca | 0:1 | ||||
| 10. Jornada | 12.03.2022 | Club Necaxa | - | Gallos Blancos | 1:0 | ||||
| 11. Jornada | 20.03.2022 | Pumas UNAM | - | Club Necaxa | 1:3 | |
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| 12. Jornada | 03.04.2022 | Club Necaxa | - | CF América | 0:1 | ||||
| 13. Jornada | 08.04.2022 | Atlas Guadalajara | - | Club Necaxa | 2:1 | ||||
| 14. Jornada | 16.04.2022 | Club Necaxa | - | Atlético San Luis | 4:2 | ||||
| 15. Jornada | 20.04.2022 | Club Necaxa | - | UANL Tigres | 2:0 | ||||
| 16. Jornada | 23.04.2022 | Puebla FC | - | Club Necaxa | 0:1 | ||||
| 17. Jornada | 30.04.2022 | Club Necaxa | - | Deportivo Guadalajara | 0:1 | |
México