| 1. Jornada | 04.07.2022 | Santos Laguna | - | CF Monterrey | 4:3 |  |
 |
||
| 2. Jornada | 09.07.2022 | Puebla FC | - | Santos Laguna | 1:0 | |
|||
| 3. Jornada | 17.07.2022 | Santos Laguna | - | Deportivo Guadalajara | 1:1 | |
|||
| 4. Jornada | 24.07.2022 | Deportivo Toluca | - | Santos Laguna | 2:1 | ||||
| 6. Jornada | 01.08.2022 | Santos Laguna | - | Atlas Guadalajara | 1:0 | ||||
| 7. Jornada | 07.08.2022 | Santos Laguna | - | Cruz Azul | 4:0 | ||||
| 8. Jornada | 15.08.2022 | UANL Tigres | - | Santos Laguna | 2:0 | |
|||
| 9. Jornada | 19.08.2022 | Santos Laguna | - | Club León | 2:1 | ||||
| 10. Jornada | 21.08.2022 | Pumas UNAM | - | Santos Laguna | 1:5 | |
|||
| 16. Jornada | 26.08.2022 | Club Tijuana | - | Santos Laguna | 0:2 | |
|||
| 12. Jornada | 04.09.2022 | CF Pachuca | - | Santos Laguna | 2:0 | ||||
| 13. Jornada | 07.09.2022 | Santos Laguna | - | Club Necaxa | 3:1 | ||||
| 14. Jornada | 11.09.2022 | Gallos Blancos | - | Santos Laguna | 3:3 | |
|||
| 5. Jornada | 15.09.2022 | CF América | - | Santos Laguna | 3:3 | |
|||
| 15. Jornada | 19.09.2022 | Santos Laguna | - | FC Juárez | 2:0 | ||||
| 17. Jornada | 03.10.2022 | Santos Laguna | - | Mazatlán FC | 3:0 | |
Uruguay
