| 8. Jornada | 27.08.2022 | Libertad | - | Guaraní | 2:2 | ||||
| 10. Jornada | 11.09.2022 | Tacuary | - | Guaraní | 2:0 | ||||
| 12. Jornada | 20.09.2022 | Guaraní | - | Club Olimpia | 2:1 | ||||
| 13. Jornada | 24.09.2022 | General Caballero DJLM | - | Guaraní | 3:0 | ||||
| 14. Jornada | 04.10.2022 | Guaraní | - | Resistencia SC | 0:1 | ||||
| 15. Jornada | 07.10.2022 | 12 de Octubre de Itauguá | - | Guaraní | 0:1 |  |
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| 16. Jornada | 13.10.2022 | Guaraní | - | Sol de América | 4:1 | ||||
| 18. Jornada | 23.10.2022 | Guaraní | - | Cerro Porteño | 1:2 | ||||
| 19. Jornada | 27.10.2022 | Guaraní | - | Libertad | 1:2 | ||||
| 20. Jornada | 30.10.2022 | Guaireña FC | - | Guaraní | 1:0 | ||||
| 21. Jornada | 06.11.2022 | Guaraní | - | Tacuary | 2:1 |  |
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| 22. Jornada | 13.11.2022 | Sportivo Ameliano | - | Guaraní | 4:2 |
Paraguay