| 23. Jornada | 13.02.2022 | CyD Leonesa | - | Unionistas CF | 0:1 | ||||
| 24. Jornada | 19.02.2022 | Extremadura UD | - | CyD Leonesa | 1:3 |  |
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| 25. Jornada | 26.02.2022 | CyD Leonesa | - | CD Tudelano | 3:1 |  |
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| 26. Jornada | 04.03.2022 | Rayo Majadahonda | - | CyD Leonesa | 1:0 | ||||
| 22. Jornada | 09.03.2022 | Real Racing | - | CyD Leonesa | 4:0 | |
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| 27. Jornada | 13.03.2022 | CyD Leonesa | - | SD Logroñés | 2:2 | ||||
| 28. Jornada | 19.03.2022 | Deportivo | - | CyD Leonesa | 2:1 | ||||
| 32. Jornada | 17.04.2022 | UD SS Reyes | - | CyD Leonesa | 0:3 | |
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| 33. Jornada | 24.04.2022 | Valladolid B | - | CyD Leonesa | 3:3 | ||||
| 34. Jornada | 01.05.2022 | CyD Leonesa | - | Zamora CF | 0:0 | ||||
| 35. Jornada | 08.05.2022 | Celta B | - | CyD Leonesa | 5:3 | ||||
| 36. Jornada | 14.05.2022 | CyD Leonesa | - | Inter de Madrid | 1:1 | |
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| 37. Jornada | 21.05.2022 | CF Talavera | - | CyD Leonesa | 0:5 | ||||
| 38. Jornada | 28.05.2022 | CyD Leonesa | - | UD Logroñés | 1:2 |
Panamá