| 1. Jornada | 24.01.2016 | River Plate | - | Cerro Porteño | 0:2 | ||||
| 2. Jornada | 29.01.2016 | Sol de América | - | River Plate | 0:1 | ||||
| 3. Jornada | 04.02.2016 | River Plate | - | Sportivo Luqueño | 0:1 | ||||
| 4. Jornada | 09.02.2016 | Libertad | - | River Plate | 3:1 | ||||
| 5. Jornada | 13.02.2016 | River Plate | - | General Caballero ZC | 0:0 |  |
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| 10. Jornada | 11.03.2016 | General Díaz | - | River Plate | 3:0 | |
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| 11. Jornada | 21.03.2016 | River Plate | - | Club Olimpia | 0:3 | ||||
| 13. Jornada | 06.04.2016 | River Plate | - | Sol de América | 1:1 | ||||
| 14. Jornada | 11.04.2016 | Sportivo Luqueño | - | River Plate | 2:0 | ||||
| 17. Jornada | 25.04.2016 | River Plate | - | Club Nacional | 1:3 | ||||
| 20. Jornada | 08.05.2016 | Club Rubio Ñu | - | River Plate | 1:2 | |
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| 21. Jornada | 14.05.2016 | River Plate | - | General Díaz | 1:1 |
Paraguay