| 1. Jornada | 24.07.2021 | Sparta Praga | - | Sigma Olomouc | 3:2 | ||||
| 2. Jornada | 31.07.2021 | Slovan Liberec | - | Sparta Praga | 0:5 |  |
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| 3. Jornada | 07.08.2021 | Sparta Praga | - | MFK Karviná | 2:0 | ||||
| 4. Jornada | 14.08.2021 | Bohemians Praha 1905 | - | Sparta Praga | 1:1 | ||||
| 5. Jornada | 21.08.2021 | Sparta Praga | - | FC Hradec Králové | 4:0 | ||||
| 6. Jornada | 28.08.2021 | Sparta Praga | - | Dynamo České Budějovice | 1:0 | ||||
| 7. Jornada | 11.09.2021 | Viktoria Plzeň | - | Sparta Praga | 3:2 | ||||
| 8. Jornada | 19.09.2021 | Sparta Praga | - | FK Jablonec | 1:1 | ||||
| 9. Jornada | 25.09.2021 | FC Fastav Zlín | - | Sparta Praga | 2:5 | ||||
| 18. Jornada | 12.12.2021 | Sparta Praga | - | Bohemians Praha 1905 | 5:1 | ||||
| 19. Jornada | 18.12.2021 | FC Hradec Králové | - | Sparta Praga | 0:1 | ||||
| 23. Jornada | 27.02.2022 | Sparta Praga | - | FC Fastav Zlín | 2:0 |  |
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| 22. Jornada | 09.03.2022 | FK Jablonec | - | Sparta Praga | 1:1 | |
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| 25. Jornada | 13.03.2022 | Sparta Praga | - | FK Pardubice | 3:1 | ||||
| 26. Jornada | 20.03.2022 | FK Mladá Boleslav | - | Sparta Praga | 0:3 | ||||
| 29. Jornada | 17.04.2022 | Sparta Praga | - | 1. FC Slovácko | 3:1 | ||||
| 30. Jornada | 20.04.2022 | Sigma Olomouc | - | Sparta Praga | 2:0 |
República Checa