| 3. Jornada | 16.10.2020 | Brescia Calcio | - | US Lecce | 3:0 | ||||
| 4. Jornada | 21.10.2020 | US Lecce | - | US Cremonese | 2:2 | ||||
| 7. Jornada | 08.11.2020 | Virtus Entella | - | US Lecce | 1:5 | ||||
| 8. Jornada | 21.11.2020 | US Lecce | - | AC Reggiana 1919 | 7:1 |  |
 |
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| 9. Jornada | 27.11.2020 | Chievo | - | US Lecce | 1:2 | |
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| 10. Jornada | 05.12.2020 | US Lecce | - | Venezia FC | 2:2 | ||||
| 11. Jornada | 12.12.2020 | US Lecce | - | Frosinone | 2:2 | ||||
| 12. Jornada | 15.12.2020 | US Salernitana 1919 | - | US Lecce | 1:1 | ||||
| 13. Jornada | 19.12.2020 | US Lecce | - | AC Pisa | 0:3 | ||||
| 14. Jornada | 22.12.2020 | SPAL 2013 Ferrara | - | US Lecce | 1:0 |
Italia