| 4. Jornada | 13.03.2021 | Delfín SC | - | Guayaquil City | 1:1 | ||||
| 5. Jornada | 21.03.2021 | Guayaquil City | - | Universidad Catolica | 1:2 | ||||
| 8. Jornada | 13.04.2021 | 9 de Octubre | - | Guayaquil City | 4:0 |  |
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| 9. Jornada | 18.04.2021 | Guayaquil City | - | LDU Quito | 2:2 | ||||
| 12. Jornada | 16.05.2021 | Emelec | - | Guayaquil City | 1:0 | |
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| 13. Jornada | 22.05.2021 | Independiente del Valle | - | Guayaquil City | 3:0 | |
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| 14. Jornada | 29.05.2021 | Guayaquil City | - | Mushuc Runa | 0:0 | |
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| 15. Jornada | 18.07.2021 | Aucas | - | Guayaquil City | 3:0 |
Ecuador