| 1. Jornada | 25.07.2021 | Macará | - | Guayaquil City | 0:2 | ||||
| 2. Jornada | 31.07.2021 | Guayaquil City | - | Deportivo Cuenca | 2:1 |  |
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| 3. Jornada | 08.08.2021 | Barcelona | - | Guayaquil City | 2:1 | ||||
| 4. Jornada | 15.08.2021 | Guayaquil City | - | Delfín SC | 2:1 | ||||
| 10. Jornada | 16.10.2021 | Guayaquil City | - | Olmedo | 4:2 | ||||
| 11. Jornada | 24.10.2021 | Manta | - | Guayaquil City | 1:1 | ||||
| 13. Jornada | 08.11.2021 | Guayaquil City | - | Independiente del Valle | 0:2 | ||||
| 14. Jornada | 21.11.2021 | Mushuc Runa | - | Guayaquil City | 1:0 | ||||
| 15. Jornada | 28.11.2021 | Guayaquil City | - | Aucas | 1:0 |
Ecuador