| 5. Jornada | 08.08.2021 | FC Cincinnati | - | Orlando City | 1:1 | ||||
| 5. Jornada | 19.08.2021 | FC Cincinnati | - | CF Montréal | 0:0 | ||||
| 5. Jornada | 22.08.2021 | New England Revolution | - | FC Cincinnati | 4:1 | ||||
| 5. Jornada | 28.08.2021 | Columbus Crew | - | FC Cincinnati | 3:2 | ||||
| 6. Jornada | 05.09.2021 | FC Cincinnati | - | Inter Miami CF | 0:1 | ||||
| 6. Jornada | 12.09.2021 | FC Cincinnati | - | Toronto FC | 2:0 |  |
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| 6. Jornada | 16.09.2021 | Atlanta United FC | - | FC Cincinnati | 4:0 | ||||
| 6. Jornada | 26.09.2021 | D.C. United | - | FC Cincinnati | 4:2 | ||||
| 6. Jornada | 30.09.2021 | Toronto FC | - | FC Cincinnati | 3:2 | |
Francia