| 1. Jornada | 27.02.2022 | San Jose Earthquakes | - | New York RB | 1:3 | ||||
| 2. Jornada | 05.03.2022 | San Jose Earthquakes | - | Columbus Crew | 3:3 |  |
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| 2. Jornada | 13.03.2022 | Philadelphia Union | - | San Jose Earthquakes | 2:0 | ||||
| 2. Jornada | 20.03.2022 | Minnesota United FC | - | San Jose Earthquakes | 1:0 |  |
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| 3. Jornada | 03.04.2022 | San Jose Earthquakes | - | Austin FC | 2:2 | |
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| 3. Jornada | 10.04.2022 | Houston Dynamo | - | San Jose Earthquakes | 4:3 | ||||
| 3. Jornada | 16.04.2022 | San Jose Earthquakes | - | Nashville SC | 2:2 | ||||
| 3. Jornada | 24.04.2022 | San Jose Earthquakes | - | Seattle Sounders | 4:3 | |
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| 4. Jornada | 01.05.2022 | New York City FC | - | San Jose Earthquakes | 3:0 | ||||
| 4. Jornada | 08.05.2022 | San Jose Earthquakes | - | Colorado Rapids | 1:0 | |
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| 4. Jornada | 15.05.2022 | Vancouver Whitecaps | - | San Jose Earthquakes | 3:3 | ||||
| 4. Jornada | 19.05.2022 | San Jose Earthquakes | - | Portland Timbers | 3:2 | ||||
| 4. Jornada | 23.05.2022 | San Jose Earthquakes | - | Sporting Kansas City | 1:1 |
Costa Rica