| 1. Jornada | 02.07.2022 | CF América [Sub 20] | - | Atlas Guadalajara [Sub 20] | 3:0 |  |
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| 2. Jornada | 09.07.2022 | CF Monterrey [Sub 20] | - | CF América [Sub 20] | 1:3 | |
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| 4. Jornada | 23.07.2022 | Club Tijuana [Sub 20] | - | CF América [Sub 20] | 3:3 | |
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| 6. Jornada | 31.07.2022 | Club León [Sub 20] | - | CF América [Sub 20] | 1:0 | ||||
| 7. Jornada | 07.08.2022 | CF América [Sub 20] | - | FC Juárez [Sub 20] | 1:1 | ||||
| 8. Jornada | 13.08.2022 | Pumas UNAM [Sub 20] | - | CF América [Sub 20] | 1:1 | ||||
| 9. Jornada | 17.08.2022 | CF Pachuca [Sub 20] | - | CF América [Sub 20] | 0:0 | ||||
| 10. Jornada | 20.08.2022 | CF América [Sub 20] | - | Cruz Azul [Sub 20] | 2:0 | |
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| 16. Jornada | 23.08.2022 | Gallos Blancos [Sub 20] | - | CF América [Sub 20] | 1:3 | |
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| 11. Jornada | 26.08.2022 | Mazatlán FC [Sub 20] | - | CF América [Sub 20] | 4:4 | |
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| 17. Jornada | 30.09.2022 | Puebla FC [Sub 20] | - | CF América [Sub 20] | 1:1 |
México