| 1. Jornada | 20.01.2008 | Cruz Azul | - | Santos Laguna | 1:1 | ||||
| 2. Jornada | 27.01.2008 | Santos Laguna | - | Deportivo Toluca | 2:2 | ||||
| 3. Jornada | 02.02.2008 | Veracruz (old) | - | Santos Laguna | 1:1 |  |
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| 4. Jornada | 10.02.2008 | Santos Laguna | - | CF Pachuca | 2:1 | |
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| 5. Jornada | 14.02.2008 | Deportivo Guadalajara | - | Santos Laguna | 3:2 | |
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| 6. Jornada | 17.02.2008 | Santos Laguna | - | Atlante | 3:0 | |
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| 7. Jornada | 24.02.2008 | CF América | - | Santos Laguna | 0:1 | ||||
| 8. Jornada | 02.03.2008 | Santos Laguna | - | CF Monterrey | 2:0 | ||||
| 9. Jornada | 09.03.2008 | Puebla FC | - | Santos Laguna | 3:3 | |
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| 10. Jornada | 16.03.2008 | Santos Laguna | - | Jaguares Chiapas | 1:3 | ||||
| 11. Jornada | 23.03.2008 | Pumas UNAM | - | Santos Laguna | 1:1 | ||||
| 13. Jornada | 06.04.2008 | Monarcas Morelia | - | Santos Laguna | 0:0 | ||||
| 14. Jornada | 13.04.2008 | Santos Laguna | - | Atlas Guadalajara | 6:1 | ||||
| 15. Jornada | 20.04.2008 | Santos Laguna | - | Club Necaxa | 1:1 | ||||
| 16. Jornada | 27.04.2008 | UANL Tigres | - | Santos Laguna | 1:2 | ||||
| 17. Jornada | 04.05.2008 | Santos Laguna | - | Club San Luis | 4:1 |
México