| 2. Jornada | 15.02.2022 | River Plate II | - | Patronato de Paraná II | 1:0 | ||||
| 3. Jornada | 19.02.2022 | Newell's Old Boys II | - | River Plate II | 1:2 | ||||
| 4. Jornada | 24.02.2022 | River Plate II | - | Racing Club II | 4:2 | ||||
| 5. Jornada | 04.03.2022 | San Lorenzo II | - | River Plate II | 0:4 | ||||
| 6. Jornada | 10.03.2022 | River Plate II | - | Gimnasia de La Plata II | 2:4 | ||||
| 7. Jornada | 18.03.2022 | River Plate II | - | Boca Juniors II | 0:0 | ||||
| 8. Jornada | 01.04.2022 | Defensa y Justicia II | - | River Plate II | 2:0 | ||||
| 10. Jornada | 14.04.2022 | Banfield II | - | River Plate II | 2:3 | ||||
| 11. Jornada | 20.04.2022 | Talleres de Córdoba II | - | River Plate II | 1:1 | ||||
| 12. Jornada | 25.04.2022 | River Plate II | - | Atlético Tucumán II | 4:0 | ||||
| 13. Jornada | 29.04.2022 | Sarmiento de Junín II | - | River Plate II | 1:2 | ||||
| 14. Jornada | 05.05.2022 | River Plate II | - | Platense II | 2:2 |  |
Argentina