| 2. Jornada | 23.02.2022 | San Luis | - | CD Magallanes | 0:2 | ||||
| 3. Jornada | 03.03.2022 | Barnechea | - | San Luis | 3:1 | ||||
| 4. Jornada | 10.03.2022 | San Luis | - | Santiago Wanderers | 1:1 | ||||
| 5. Jornada | 17.03.2022 | San Luis | - | Santiago Morning | 1:2 | ||||
| 6. Jornada | 23.03.2022 | Rangers | - | San Luis | 2:3 | ||||
| 8. Jornada | 12.04.2022 | Unión San Felipe | - | San Luis | 2:0 |  |
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| 9. Jornada | 18.04.2022 | San Luis | - | Deportes Melipilla | 2:1 | ||||
| 10. Jornada | 22.04.2022 | Puerto Montt | - | San Luis | 1:1 | ||||
| 12. Jornada | 30.04.2022 | San Luis | - | Deportes Temuco | 1:1 | ||||
| 13. Jornada | 07.05.2022 | Deportes Iquique | - | San Luis | 1:1 | ||||
| 14. Jornada | 13.05.2022 | San Luis | - | Fernández Vial | 0:0 | |
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| 15. Jornada | 18.05.2022 | Santa Cruz | - | San Luis | 2:0 | ||||
| 16. Jornada | 24.05.2022 | Recoleta | - | San Luis | 2:3 | ||||
| 19. Jornada | 09.07.2022 | CD Magallanes | - | San Luis | 3:0 | ||||
| 24. Jornada | 16.08.2022 | Deportes Copiapó | - | San Luis | 1:1 | ||||
| 26. Jornada | 31.08.2022 | Deportes Melipilla | - | San Luis | 1:2 | ||||
| 29. Jornada | 27.09.2022 | Deportes Temuco | - | San Luis | 1:0 | ||||
| 31. Jornada | 10.10.2022 | Fernández Vial | - | San Luis | 1:1 |
Chile