| 1. Jornada | 08.01.2018 | Santos Laguna | - | Lobos BUAP | 4:2 |  |
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| 2. Jornada | 14.01.2018 | Lobos BUAP | - | Gallos Blancos | 0:2 | ||||
| 3. Jornada | 21.01.2018 | CF Pachuca | - | Lobos BUAP | 3:1 | ||||
| 4. Jornada | 28.01.2018 | Lobos BUAP | - | Pumas UNAM | 1:1 | ||||
| 5. Jornada | 04.02.2018 | CF América | - | Lobos BUAP | 5:1 | ||||
| 6. Jornada | 11.02.2018 | Lobos BUAP | - | Atlas Guadalajara | 3:1 | ||||
| 7. Jornada | 14.02.2018 | Lobos BUAP | - | UANL Tigres | 0:0 | ||||
| 8. Jornada | 17.02.2018 | Monarcas Morelia | - | Lobos BUAP | 2:1 | ||||
| 9. Jornada | 25.02.2018 | Lobos BUAP | - | CD Veracruz | 5:0 | |
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| 10. Jornada | 03.03.2018 | Club Tijuana | - | Lobos BUAP | 3:1 | ||||
| 11. Jornada | 11.03.2018 | Lobos BUAP | - | Deportivo Guadalajara | 0:1 |  |
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| 12. Jornada | 18.03.2018 | Club León | - | Lobos BUAP | 2:2 | ||||
| 13. Jornada | 01.04.2018 | Lobos BUAP | - | Deportivo Toluca | 1:2 | ||||
| 15. Jornada | 15.04.2018 | Lobos BUAP | - | Club Necaxa | 0:1 |
Ecuador