| 1. Jornada | 22.02.2021 | Alianza | - | Sporting San Miguelito | 0:0 | ||||
| 2. Jornada | 28.02.2021 | Sporting San Miguelito | - | Plaza Amador | 0:0 |  |
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| 4. Jornada | 13.03.2021 | Deportivo del Este | - | Sporting San Miguelito | 1:1 |  |
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| 5. Jornada | 18.03.2021 | Sporting San Miguelito | - | Árabe Unido | 3:2 | ||||
| 7. Jornada | 24.03.2021 | Sporting San Miguelito | - | Independiente de La Chorrera | 1:3 | ||||
| 8. Jornada | 29.03.2021 | Sporting San Miguelito | - | Veraguas Club Deportivo | 1:1 | ||||
| 9. Jornada | 05.04.2021 | Herrera FC | - | Sporting San Miguelito | 2:0 | ||||
| 10. Jornada | 10.04.2021 | San Francisco FC | - | Sporting San Miguelito | 2:0 | ||||
| 11. Jornada | 17.04.2021 | Sporting San Miguelito | - | Atlético Chiriquí | 2:1 |  |
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| 12. Jornada | 21.04.2021 | Sporting San Miguelito | - | Alianza | 0:0 | |
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| 13. Jornada | 25.04.2021 | Plaza Amador | - | Sporting San Miguelito | 2:1 | ||||
| 14. Jornada | 28.04.2021 | Sporting San Miguelito | - | Tauro FC | 2:2 | ||||
| 15. Jornada | 06.05.2021 | Sporting San Miguelito | - | Deportivo del Este | 1:0 |
Panamá