| 7. Jornada | 27.08.2021 | Mazatlán FC [Sub 18] | - | Atlético San Luis [Sub 18] | 5:1 | ||||
| 9. Jornada | 18.09.2021 | Mazatlán FC [Sub 18] | - | Pumas UNAM [Sub 18] | 2:0 |  |
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| 14. Jornada | 19.10.2021 | Puebla FC [Sub 18] | - | Mazatlán FC [Sub 18] | 0:2 | ||||
| 15. Jornada | 22.10.2021 | Mazatlán FC [Sub 18] | - | Gallos Blancos [Sub 18] | 2:0 | ||||
| 17. Jornada | 05.11.2021 | Mazatlán FC [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 2:1 | |
México