| 1. Jornada | 24.07.2021 | Puebla FC [Sub 16] | - | CF Pachuca [Sub 16] | 2:3 | ||||
| 4. Jornada | 14.08.2021 | CF América [Sub 16] | - | CF Pachuca [Sub 16] | 0:1 | ||||
| 6. Jornada | 28.08.2021 | CF Pachuca [Sub 16] | - | Club Tijuana [Sub 16] | 1:0 | ||||
| 7. Jornada | 04.09.2021 | Gallos Blancos [Sub 16] | - | CF Pachuca [Sub 16] | 1:1 | ||||
| 8. Jornada | 11.09.2021 | FC Juárez [Sub 16] | - | CF Pachuca [Sub 16] | 1:0 | ||||
| 5. Jornada | 15.09.2021 | CF Pachuca [Sub 16] | - | Pumas UNAM [Sub 16] | 1:0 | ||||
| 10. Jornada | 25.09.2021 | Cruz Azul [Sub 16] | - | CF Pachuca [Sub 16] | 1:2 | ||||
| 11. Jornada | 02.10.2021 | CF Pachuca [Sub 16] | - | Puebla FC [Sub 16] | 1:1 | ||||
| 16. Jornada | 06.11.2021 | CF Pachuca [Sub 16] | - | CF América [Sub 16] | 3:1 | ||||
| 18. Jornada | 20.11.2021 | CF Pachuca [Sub 16] | - | Gallos Blancos [Sub 16] | 2:4 |
México