| 1. Jornada | 03.07.2022 | Atlético San Luis [Sub 20] | - | Club León [Sub 20] | 1:3 | ||||
| 2. Jornada | 09.07.2022 | Deportivo Guadalajara [Sub 20] | - | Atlético San Luis [Sub 20] | 3:1 | ||||
| 3. Jornada | 17.07.2022 | Atlético San Luis [Sub 20] | - | CF Monterrey [Sub 20] | 2:1 |  |
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| 4. Jornada | 22.07.2022 | Mazatlán FC [Sub 20] | - | Atlético San Luis [Sub 20] | 5:0 | ||||
| 5. Jornada | 26.07.2022 | Atlético San Luis [Sub 20] | - | Cruz Azul [Sub 20] | 0:2 | ||||
| 6. Jornada | 30.07.2022 | Puebla FC [Sub 20] | - | Atlético San Luis [Sub 20] | 2:3 | |
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| 7. Jornada | 07.08.2022 | Atlético San Luis [Sub 20] | - | Club Necaxa [Sub 20] | 2:2 | ||||
| 8. Jornada | 11.08.2022 | Gallos Blancos [Sub 20] | - | Atlético San Luis [Sub 20] | 0:3 | ||||
| 9. Jornada | 18.08.2022 | Atlético San Luis [Sub 20] | - | Pumas UNAM [Sub 20] | 0:2 | ||||
| 11. Jornada | 28.08.2022 | Santos Laguna [Sub 20] | - | Atlético San Luis [Sub 20] | 7:2 | ||||
| 12. Jornada | 01.09.2022 | Atlético San Luis [Sub 20] | - | Club Tijuana [Sub 20] | 3:2 | ||||
| 13. Jornada | 06.09.2022 | CF América [Sub 20] | - | Atlético San Luis [Sub 20] | 5:0 | ||||
| 16. Jornada | 23.09.2022 | FC Juárez [Sub 20] | - | Atlético San Luis [Sub 20] | 3:0 |
México