| 8. Jornada | 17.07.2022 | Banfield | - | San Lorenzo | 1:1 |  |
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| 9. Jornada | 20.07.2022 | San Lorenzo | - | Unión de Santa Fe | 2:2 | ||||
| 13. Jornada | 13.08.2022 | Patronato de Paraná | - | San Lorenzo | 3:2 | ||||
| 16. Jornada | 27.08.2022 | San Lorenzo | - | Rosario Central | 1:1 | ||||
| 17. Jornada | 06.09.2022 | Defensa y Justicia | - | San Lorenzo | 0:0 | ||||
| 18. Jornada | 10.09.2022 | San Lorenzo | - | Atlético Tucumán | 1:1 | ||||
| 19. Jornada | 14.09.2022 | Colón de Santa Fe | - | San Lorenzo | 0:0 | ||||
| 23. Jornada | 04.10.2022 | Godoy Cruz | - | San Lorenzo | 0:0 | ||||
| 26. Jornada | 18.10.2022 | Sarmiento de Junín | - | San Lorenzo | 2:4 |
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