| 1. Jornada | 27.01.2023 | Libertad | - | Guaraní | 1:0 |  |
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| 2. Jornada | 04.02.2023 | Guaraní | - | Sportivo Ameliano | 2:2 | ||||
| 3. Jornada | 12.02.2023 | Cerro Porteño | - | Guaraní | 1:1 | |
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| 4. Jornada | 17.02.2023 | Resistencia SC | - | Guaraní | 0:4 | |
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| 6. Jornada | 04.03.2023 | Club Nacional | - | Guaraní | 0:2 | |
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| 7. Jornada | 14.03.2023 | Guaraní | - | Tacuary | 1:0 | |
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| 9. Jornada | 24.03.2023 | Guaraní | - | Guaireña FC | 1:1 | |
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| 10. Jornada | 01.04.2023 | Club Olimpia | - | Guaraní | 0:1 |  |
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| 12. Jornada | 14.04.2023 | Guaraní | - | Libertad | 0:0 | ||||
| 16. Jornada | 06.05.2023 | Sportivo Luqueño | - | Guaraní | 3:0 | |
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| 19. Jornada | 22.05.2023 | Guaraní | - | Sportivo Trinidense | 0:2 |  |
Argentina