| 2. Jornada | 13.08.2021 | Platense | - | Honduras Progreso | 1:1 |  |
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| 3. Jornada | 15.08.2021 | Lobos UPNFM | - | Honduras Progreso | 3:0 | ||||
| 6. Jornada | 29.08.2021 | Honduras Progreso | - | Vida | 1:1 | |
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| 7. Jornada | 05.09.2021 | Honduras Progreso | - | Motagua | 0:3 | ||||
| 8. Jornada | 12.09.2021 | Real Sociedad | - | Honduras Progreso | 1:0 | |
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| 9. Jornada | 16.09.2021 | Honduras Progreso | - | Real España | 1:1 | ||||
| 10. Jornada | 20.09.2021 | Vida | - | Honduras Progreso | 1:0 | ||||
| 11. Jornada | 23.09.2021 | Victoria | - | Honduras Progreso | 1:2 | |
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| 12. Jornada | 03.10.2021 | Honduras Progreso | - | Platense | 4:2 | |
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| 13. Jornada | 09.10.2021 | Marathón | - | Honduras Progreso | 2:1 | |
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| 14. Jornada | 17.10.2021 | Honduras Progreso | - | Lobos UPNFM | 0:1 | |
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| 16. Jornada | 28.10.2021 | Real España | - | Honduras Progreso | 4:1 | ||||
| 17. Jornada | 01.11.2021 | Honduras Progreso | - | Real Sociedad | 2:1 | ||||
| 18. Jornada | 10.11.2021 | Motagua | - | Honduras Progreso | 3:2 |
Honduras