| 1. Jornada | 20.01.2022 | Honduras Progreso | - | Motagua | 2:1 | ||||
| 2. Jornada | 23.01.2022 | Honduras Progreso | - | Lobos UPNFM | 1:2 |  |
 |
||
| 3. Jornada | 06.02.2022 | Olimpia | - | Honduras Progreso | 3:0 | ||||
| 4. Jornada | 10.02.2022 | Real Sociedad | - | Honduras Progreso | 4:2 | ||||
| 5. Jornada | 13.02.2022 | Honduras Progreso | - | Marathón | 2:1 | |
|||
| 6. Jornada | 20.02.2022 | Vida | - | Honduras Progreso | 0:2 | ||||
| 16. Jornada | 21.04.2022 | Motagua | - | Honduras Progreso | 3:2 | |
|||
| 17. Jornada | 24.04.2022 | Honduras Progreso | - | Real España | 1:1 | ||||
| 18. Jornada | 01.05.2022 | Honduras Progreso | - | Platense | 3:1 | |
Honduras