| 8. Jornada | 02.03.2016 | Deportivo Capiatá | - | River Plate | 1:1 |  |
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| 9. Jornada | 05.03.2016 | River Plate | - | Club Rubio Ñu | 1:4 |  |
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| 10. Jornada | 11.03.2016 | General Díaz | - | River Plate | 3:0 | ||||
| 11. Jornada | 21.03.2016 | River Plate | - | Club Olimpia | 0:3 | ||||
| 12. Jornada | 01.04.2016 | Cerro Porteño | - | River Plate | 4:0 | ||||
| 15. Jornada | 17.04.2016 | River Plate | - | Libertad | 1:3 | ||||
| 16. Jornada | 21.04.2016 | General Caballero ZC | - | River Plate | 2:3 | ||||
| 17. Jornada | 25.04.2016 | River Plate | - | Club Nacional | 1:3 | ||||
| 20. Jornada | 08.05.2016 | Club Rubio Ñu | - | River Plate | 1:2 | |
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| 21. Jornada | 14.05.2016 | River Plate | - | General Díaz | 1:1 | ||||
| 22. Jornada | 22.05.2016 | Club Olimpia | - | River Plate | 3:0 |
Paraguay