| 2. Jornada | 19.09.2021 | Asteras Tripolis | - | PAOK Saloniki | 0:1 |  |
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| 3. Jornada | 22.09.2021 | Panetolikos | - | PAOK Saloniki | 1:2 | ||||
| 4. Jornada | 26.09.2021 | PAOK Saloniki | - | AEK Athen | 2:0 | ||||
| 5. Jornada | 03.10.2021 | OFI Heraklion | - | PAOK Saloniki | 1:3 | ||||
| 6. Jornada | 17.10.2021 | PAOK Saloniki | - | Volos NFC | 4:4 | |
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| 7. Jornada | 24.10.2021 | Olympiacos | - | PAOK Saloniki | 2:1 | ||||
| 8. Jornada | 30.10.2021 | PAOK Saloniki | - | Apollon Smyrnis | 4:1 |  |
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| 9. Jornada | 07.11.2021 | Panathinaikos | - | PAOK Saloniki | 1:3 | |
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| 11. Jornada | 28.11.2021 | PAOK Saloniki | - | Aris Saloniki | 0:1 | ||||
| 12. Jornada | 05.12.2021 | Ionikos Nikea | - | PAOK Saloniki | 3:2 | ||||
| 13. Jornada | 12.12.2021 | PAOK Saloniki | - | Lamia | 2:1 | |
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| 16. Jornada | 12.01.2022 | PAOK Saloniki | - | Panetolikos | 2:0 | ||||
| 19. Jornada | 23.01.2022 | Volos NFC | - | PAOK Saloniki | 0:4 | ||||
| 21. Jornada | 02.02.2022 | Apollon Smyrnis | - | PAOK Saloniki | 0:2 | ||||
| 22. Jornada | 06.02.2022 | PAOK Saloniki | - | Panathinaikos | 2:1 | ||||
| 24. Jornada | 20.02.2022 | Aris Saloniki | - | PAOK Saloniki | 0:0 | ||||
| 25. Jornada | 27.02.2022 | PAOK Saloniki | - | Ionikos Nikea | 1:1 | |
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| 26. Jornada | 06.03.2022 | Lamia | - | PAOK Saloniki | 0:2 | |
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Grecia