| 3. Jornada | 19.02.2022 | The Strongest | - | Universitario de Sucre | 1:1 |  |
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| 4. Jornada | 26.02.2022 | Real Santa Cruz | - | The Strongest | 1:2 | ||||
| 6. Jornada | 15.03.2022 | The Strongest | - | Bolívar | 0:1 | ||||
| 7. Jornada | 03.04.2022 | CD Guabirá | - | The Strongest | 1:3 | |
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| 9. Jornada | 18.04.2022 | Oriente Petrolero | - | The Strongest | 1:1 | |
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| 10. Jornada | 21.04.2022 | The Strongest | - | Atlético Palmaflor | 4:1 | ||||
| 12. Jornada | 30.04.2022 | The Strongest | - | Real Santa Cruz | 1:1 | ||||
| 13. Jornada | 08.05.2022 | Bolívar | - | The Strongest | 1:0 | ||||
| 14. Jornada | 12.05.2022 | Nacional Potosí | - | The Strongest | 1:1 |
Uruguay